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There are two major safety concerns with isotretinoin: It is teratogenic at all therapeutic doses and durations of exposure It may be linked to depressive illness or suicidal ideation. From March 1, general practitioners GPs and nurse practitioners have become eligible to prescribe funded isotretinoin, under special authority. Countries such as the UK and Australia debated the same issues, but the outcome was that specialist restriction of isotretinoin remained. It is, however, a highly effective treatment for severe roaccutane cost australia that has not responded to any other therapy. Isotretinoin should be available, but prescribing must be closely aligned with extreme vigilance in providing concurrent contraception and counselling about its teratogenic effects, and monitoring for behavioural changes. In concern was raised by Australian pharmacists that some prescribers of isotretinoin predominantly dermatologists were not warning patients about teratogenicity, did not prescribe concurrent contraception and had not documented any pregnancy tests.

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