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Often the condition is mediated by the immune system through inhalation of an antigen to which the individual is allergic. The antigen reacts with IgE attached to the mast cells in the lung causing the release of pharmacologically active mediators. These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes).
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Around the central core of the brain are a number of structures that collectively make up the deep brain nuclei, which are organized into the limbic system, and the basal nuclei.
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ACE inhibitors have no effect on heart rate or bronchioles, lipid levels or the action of insulin and therefore can be used safely in patients with heart failure, asthma, peripheral vascular disease or diabetes.
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