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Benzodiazepines also require special precaution if used by individuals that may be pregnant, alcohol- or drug-dependent, or may have comorbid psychiatric disorders. Clonazepam is not recommended for use in those under Use in very young children may be especially hazardous. Of anticonvulsant drugs, behavioural disturbances occur most frequently with clonazepam and phenobarbital. Clonazepam may aggravate hepatic porphyria.

Clonazepam is not recommended for patients with chronic schizophrenia. A double-blinded, placebo-controlled study found clonazepam increases violent behavior in individuals with chronic schizophrenia. Clonazepam has similar effectiveness to other benzodiazepines at often a lower dose. Clonazepam decreases the levels of carbamazepine, 97 98 and, likewise, clonazepam's level is reduced by carbamazepine. Azole antifungals, such as ketoconazole, may inhibit the metabolism of clonazepam.

Combined use of clonazepam with certain antidepressants, anticonvulsants such as phenobarbital, phenytoin, and carbamazepine, sedative antihistamines, opiates, and antipsychotics, nonbenzodiazepines such as zolpidem, and alcohol may result in enhanced sedative effects. The data are also inconclusive on whether benzodiazepines such as clonazepam cause developmental deficits or decreases in IQ in the developing fetus when taken by the mother during pregnancy. Clonazepam, when used late in pregnancy, may result in the development of a severe benzodiazepine withdrawal syndrome in the neonate.

Withdrawal symptoms from benzodiazepines in the neonate may include hypotonia, apnoeic spells, cyanosis, and impaired metabolic responses to cold stress. The safety profile of clonazepam during pregnancy is less clear than that of other benzodiazepines, and if benzodiazepines are indicated during pregnancy, chlordiazepoxide and diazepam may be a safer choice. The use of clonazepam during pregnancy should only occur if the clinical benefits are believed to outweigh the clinical risks to the fetus.

Caution is also required if clonazepam is used during breastfeeding. Neonatal withdrawal syndrome associated with benzodiazepines include hypertonia, hyperreflexia, restlessness, irritability, abnormal sleep patterns, inconsolable crying, tremors, or jerking of the extremities, bradycardia, cyanosis, suckling difficulties, apnea, risk of aspiration of feeds, diarrhea and vomiting, and growth retardation.

This syndrome can develop between three days to three weeks after birth and can have a duration of up to several months. The pathway by which clonazepam is metabolized is usually impaired in newborns. If clonazepam is used during pregnancy or breastfeeding, it is recommended that serum levels of clonazepam are monitored and that signs of central nervous system depression and apnea are also checked for.

In many cases, non-pharmacological treatments, such as relaxation therapy, psychotherapy, and avoidance of caffeine, can be an effective and safer alternative to the use of benzodiazepines for anxiety in pregnant women. Clonazepam enhances the activity of the inhibitory neurotransmitter Gamma-Aminobutyric acid GABA in the central nervous system to give its anticonvulsant, skeletal muscle relaxant, and anxiolytic effects.

This further results in an inhibition of synaptic transmission across the central nervous system. Benzodiazepines do not have any effect on the levels of GABA in the brain. Clonazepam does, however, affect glutamate decarboxylase activity.

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First, when people need quick and easy treatment for their anxiety signs in daily life, Diazepam 10mg pills can help a lot. Again, experts say Valium over the counter pills help people to live a normal life. At the same time, some people mix alcohol and Diazepam pills to ease their stress signs, which is. The medication, which is FDA approved, is also recommended for people who suffer from excessive worry and face difficulty sleeping peacefully at night. The stimulating GABA receptors in the brain help to cool down the central nervous system by producing a calming and relaxing effect into the body.

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