Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension. It is in the phosphodiesterase-5 inhibitor PDE5-I class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. Objectives: Explain the mechanism of action of sildenafil in the treatment of erectile dysfunction and pulmonary arterial hypertension. Outline appropriate monitoring of sildenafil therapy in erectile dysfunction and pulmonary arterial hypertension. Sildenafil was the first phosphodiesterase-5 PDE5 inhibitor approved for use, receiving US Food and Drug Administration approval for use in erectile dysfunction on March 27, Sildenafil also has FDA approval for the treatment of World Health Organization Group I pulmonary hypertension also known as pulmonary arterial hypertension PAH in adults to improve exercise tolerance and delay clinical worsening.

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