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To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting PONV in patients undergoing total hip replacement or total knee replacement procedures. The cost-effectiveness analysis model was applied to data derived from a previous clinical study conducted in and This study involved 78 adult patients The incidence of PONV and use of rescue antiemetics was significantly greater in the ondansetron group compared with the prochlorperazine group. The mean total costs of PONV management per patient in the prochlorperazine and ondansetron groups were dollar

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