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In the present studies, the soluble glucocorticoid agonist, decadron phosphate DEC, was administered i. Concentrations of ir- and bioPRL in samples obtained before and after drug treatments were determined by standard PRL radioimmunoassay and the Nb2 rat node lymphoma bioassay, respectively. The magnitude and duration of this drug-induced decline in biopotency of secreted hormone was dose-dependent. Circulating levels of ir- and bioPRL were not altered in rats injected i. Neither of the two larger i. The present results provide evidence that glucocorticoids may modulate pituitary lactotrope function in part through inhibitory neuroendocrine mechanisms initiated within the brain, and suggest that glucocorticoid receptors may exist within neural pathways that regulate pituitary PRL secretion. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Abstract In the present studies, the soluble glucocorticoid agonist, decadron phosphate DEC, was administered i. Citing articles via Web of Science 8.

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