The trial is designed to demonstrate the significance of using PhosLo plus Lipitor as a combination therapy to optimize cardiovascular health in ESRD patients. Cardiac illness is a major contributor to deaths in ESRD patients. Consequently, we believe treatment that lipid-lowering agents such as statins will become the standard of care for ESRD patients. In addition, there is a growing body of evidence, including the recent data presented at the American Diabetes Association, that states use of a statin, even in patients with normal cholesterol levels, can provide significant medical benefits. The primary endpoint in the study will be the measurement of cardiovascular calcification by Electron Beam Computer Tomography EBCT, an accepted analytical measurement tool for the assessment and quantification of cardiovascular calcification.

The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. The journal accepts submissions of articles in English and in Spanish languages. SRJ is a prestige metric based on the idea that not all citations are the same. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. The controversy alluded to in the title has arisen due to substantial differences in price between two different types of phosphate binders: those that contain calcium lower price and those that are calcium free higher price. I defend the opinion that price should not determine the choice made by doctors upon which drug to administer, in this case phosphate binders.

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Phosphate binders are medications used to reduce the absorption of dietary phosphate ; they are taken along with meals and snacks. They are frequently used in people with chronic kidney failure CKF, who are less able to excrete phosphate, resulting in an elevated serum phosphate. These agents work by binding to phosphate in the GI tract, thereby making it unavailable to the body for absorption. Hence, these drugs are usually taken with meals to bind any phosphate that may be present in the ingested food. Phosphate binders such as sevelamer may also be polymeric structures which bind to phosphate and are then excreted. For people with chronic kidney failure, controlling serum phosphate is important because it is associated with bone pathology and regulated together with serum calcium by the parathyroid hormone PTH. They are also used in hypoparathyroidism which presents with hypocalcemia with hyperphosphatemia. With regard to phosphate binders, aluminium-containing compounds such as aluminium hydroxide are the least preferred because prolonged aluminium intake can cause encephalopathy and osteomalacia. One may avoid these adverse effects by using phosphate binders that do not contain calcium or aluminium as active ingredients, such as lanthanum carbonate or sevelamer.

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Unless explicitly stated, any brand names included in brackets next to a drug's generic name are there solely to aid searching and identification, and should not be considered to limit use to that specific brand. Calcium Salts calcium acetate. Calcium Salts calcium carbonate. Phosphate binder - hyperphosphataemia in patients on haemodialysis and peritoneal dialysis. Amber Drug Guidance - lanthanum.

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Whereas insufficient calcium supply may cause deficient mineralization of the skeleton, calcium overload may be associated with severe vascular morbidity. Adequate dietary calcium intake during childhood is necessary for skeletal development, including acquisition of an optimal peak bone mass during puberty. Spontaneous calcium intake frequently is insufficient in adolescent patients in whom acceptance of high-calcium foods is limited and in children on phosphorus-restricted diets. The homeostatic mechanisms for regulating calcium balance are impaired most severely in children with CKD stage 5 and on dialysis therapy. Calcium absorption cannot be adjusted because of the kidney's inability to produce 1,25 OH 2 D. Also, vitamin D receptor expression may be reduced.

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