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Dopamine agonists have been used as adjunctive therapy for acromegaly for many years, but relatively few studies have assessed the efficacy of a newer agonist, cabergoline. Some data suggest that cabergoline may be more effective than bromocriptine, in particular for those patients whose tumors secrete both growth hormone and prolactin. We describe first an unusual patient who presented with a pituitary macroadenoma secreting both GH and prolactin. At presentation he had elevated levels of growth hormone 6. Cabergoline therapy alone was highly effective in this patient and normalized his levels of all three hormones and his gonadal function as well as produced significant shrinkage of his pituitary tumor.

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Cabergoline is used to treat hyperprolactinemia high levels of prolactin, a natural substance that helps breast-feeding women produce milk but can cause symptoms such as infertility, sexual problems, and bone loss in women who are not breast-feeding or men. It works by decreasing the amount of prolactin in the body. Your doctor will probably start you on a low dose of cabergoline and gradually increase your dose, not more often than once every 4 weeks. Do not stop taking cabergoline without talking to your doctor. Your doctor will probably decrease your dose gradually.

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