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Immediate-release oxybutynin was the gold standard for pharmacologic treatment of overactive bladder for nearly 30 years. Intolerable systemic side effects, in particular dry mouth, limited its clinical utility, resulting in poor patient compliance with dosing regimens.

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The introduction of generic Actos should substantially reduce the price of the drug. This means Actos now has significant potential as a low-cost treatment for type 2 diabetes, which could mean healthcare providers will become more likely to recommend its use.

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He also still appears in films as one of the highest-paid actors worldwide.

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Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are not candidates for surgery or for patients with bilateral micro or macronodular adrenal hyperplasia idiopathic hyperaldosteronism.
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