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Other genetic variants of drug metabolism may have a similar impact: a defect of N- acetyltransferase 2 impedes the N-acetyla- tion of diverse drugs, including isoniazid, hydralazine, sulfonamides, clonazapam, and nitrazepam. Ad- drug to placebo and vice versa can be made ministration of a placebo may elicit the de- in a successive phase of treatment, the cross- sired effect relief of symptoms or unde- over trial. |
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According to the manufacturers, these antidepressants can be dosed up to a maximum daily dose as indicated in the table below. |












