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By the late s, paroxetine frequently was being associated with serious drug interactions and medication side effects. Most significantly, in a major Canadian epidemiological study examining the relationship between antidepressants and diseases, paroxetine was associated with a percent increase in the rate of breast cancer in women who had taken it over a four-year period. |
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Competing interests: The authors have declared that no competing interests exist. |
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SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption reuptake into the presynaptic cell. SSRIs are the most widely prescribed antidepressants in many countries. |
