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Sildenafil Citrate is an inhibitor of phosphodiesterase 5 PDE5, which catalyzes the hydrolysis of cyclic guanosine monophosphate cGMP in regulating cellular responses to a number of extracellular signals. Sildenafil Citrate treatment of a porcine model of cardiac arrest and resuscitation produced a cardioprotective effect, improving cardiac function and survival while reducing apoptosis 4. |
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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. |
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